Comparative mycobacterial genomics as a tool for drug target and antigen discovery
نویسندگان
چکیده
منابع مشابه
Comparative mycobacterial genomics as a tool for drug target and antigen discovery.
Genomics and the associated downstream technologies are generating vast data sets that provide new opportunities for understanding and combating both infectious and genetic diseases in humans. The genomic approach has been applied to tuberculosis, a major cause of transmissible morbidity and mortality, with notable success. Complete genome sequences are now available for three members of the My...
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Despite the introduction of the first line treatment regimen forty years ago and the continuous trials since that time to introduce new regimens, tuberculosis (TB) is considered to be the cause of considerable mortality worldwide. Recent research highlighted the Mycobacterium tuberculosis (Mtb)CYP450s as potential drug targets. This article reviews mycobacterial CYP121 as a target for anti-TB d...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2002
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.02.00400202